The Penn Center for Musculoskeletal Disorders (PCMD) will continue to enhance the research productivity and provide critical resources and programs to investigators, with a wide variety of expertise, to address multidisciplinary research strategies for musculoskeletal problems. The overall goal of this Center is to promote a cooperative interaction among investigators to enhance the effectiveness of ongoing research and promote new research. We will continue the theme of Musculoskeletal Tissue Injury and Repair for our Center. This theme is both broad (as it includes all musculoskeletal tissue types, such as bone, cartilage, disc, ligament, meniscus, muscle, and tendon), focused (as it includes similarities of approaches across all tissue types, with particular emphasis on applications using small animal models), and clinically significant (as it fosters development of assays, procedures and new knowledge with direct translational relevance). It is important to note that our PCMD is not a bone center, nor is it a muscle center. Indeed, one of the major strengths that differentiate our efforts is our inclusive home for all musculoskeletal researchers at Penn. Thus, the primary aims of this Center are to enhance and advance the research productivity of investigators in musculoskeletal tissue injury and repair by: Aim 1: Developing critical research core facilities in fundamental areas that cross disciplines and hierarchies. These core facilities are Molecular Profiling, Histology, Biomechanics, and Imaging. Aim 2: Developing a pilot and feasibility grant program for new and established investigators whereby new approaches, ideas, and collaborations can be developed prior to seeking extramural funding, and, Aim 3: Developing educational, training, and research enrichment programs for the musculoskeletal community spanning multiple tissue types, research approaches, and paradigms, through which investigators can learn from each other, and from national leaders, in areas where they are not expert.